Biotechnologists at ETH-Zurich have created a genetic helper that could one day put an end to the hunger pains.The new genetic slimming aid developed at ETH-Zurich can be implanted in a capsule. The capsule contains human cells that have been implanted with a complex regulatory circuit that was created by combining different human genes that produce proteins and reaction steps.
Unlike invasive tummy-tying approaches, such as laparoscopic adjustable gastric bands or stomach stapling, the new genetic slimming aid developed at ETH-Zurich can be implanted in a capsule. The capsule contains human cells that have been implanted with a complex regulatory circuit that was created by combining different human genes that produce proteins and reaction steps.
When released, the synthetic genetic circuit constantly monitors the levels of fat circulating in the blood and, when excessively high fat levels are detected, it produces a hormone that makes the body feel satiated, thus suppressing appetite. The researchers say the circuit can measure several types of fat, including several saturated and unsaturated animal and vegetable fats that are ingested at once.
The research group, headed by ETH-Zurich professor Martin Fussenegger, tested the genetic regulatory circuit on obese mice that had been fed a diet of fatty food. Capsules containing the circuit were implanted in the mice, which then stopped eating excessively and started to lose bodyweight. After their blood-fat levels returned to normal, the circuit stopped producing the satiety-signaling substance.
“The mice lost weight although we kept giving them as much high-calorie food as they could eat,” says Fussenegger, who added that mice fed a diet of normal animal feed with a five-percent fat content didn't reduce their food intake or lose weight.
Source: Gizmag
